Senior Scientist (NGS, Single-cell genomics, spatial transcriptomics)

The highly successful Laboratory for Inflammatory Skin Diseases at the Kimberly and Eric J. Waldman Department of Dermatology at Icahn School of Medicine at Mount Sinai, which is responsible for exciting discoveries leading to the development of new treatments, is seeking a highly motivated Senior PhD-Level Scientist to join our expanding lab. The ideal candidate will work independently to design, execute, and interpret molecular and cellular assays and is comfortable in a fast-paced academic and entrepreneurial environment.

This vital role will be responsible for the laboratory's genomics (NGS, Single Cell, and Special transcriptomics) and proteomics (Olink proteomics) aspects, ensuring timely completion of research projects and training and supervising assigned Research Associates.

This is a full-time on-site wet lab role. As a valuable team member, you will contribute to the NGS, Sigle Cell, and Special Transcriptomics studies underlying new treatments for Inflammatory Skin Disorders. You will be responsible for running and troubleshooting scientific experiments, working in a cohesive cross-functional setting, and supporting a team environment.

Responsibilities

• Execute and implement complex lab protocols to characterize skin and blood samples.
• Execute assay and reagent troubleshooting, optimization, validation of experiments, and appropriate documentation to support procedures and protocols, including data capture, forms, logbooks, and inventory batch records.
• On-boarding and development of new assays and troubleshooting where required
• Keep detailed records of work and testing
• Supervise method and instrument qualification and validation.
• Summarize methods for publications and assist with publications for scientific journals.
• Effectively plan and ensure project deliverables and timelines are met.
• Train and mentor junior staff and research fellows to implement new technologies

Qualifications

• PhD plus three years of postdoctoral or industrial hands-on lab work experience in NGS, Single Cell, and/or Spatial transcriptomics (required).
• Experience must be documented through notable authorship in peer-reviewed publications or equivalent industrial exposure (required).
• Experience with platforms of 10X Chromium, Vizgen-MERSCOPE or 10X Visium/Xenium, or Nanostring GeoMx (strongly preferred)
• Ability to work both independently and collaboratively in a team environment (required)
• Effective communication skills (required) and ability to document and present research findings
• Willingness to learn, adapt, and support a cohesive team environment
• Excellent attention to detail and ability to follow protocols accurately
• Strong analytical and problem-solving skills
• A minimum 2-year commitment is required.