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Principal Scientist, Protein Production & Process Development
Planet Pharma • Cambridge, MA 02140 • Posted 1 day ago via LinkedIn
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In-person • Full-time • Principal
Job Highlights
Using AI ⚡ to summarize the original job post
Our client, a leading Biotechnology company in Cambridge, MA, is seeking a Principal Scientist with expertise in Protein Production & Process Development. The role involves producing lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes, and engaging a diverse team to optimize processes for TCR bispecific molecules. The position requires a strong background in process development, experience with Recombinant protein, and a proven ability to lead and manage lab teams.
Responsibilities
- Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
- Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.
- Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.
- Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
- Drive team engagement, ownership, and agility to deliver ambitious results.
- Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.
Qualifications
Required
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years’ experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Strong process development background
- Experience with Recombinant protein
- Experience with bispecific protein products
About Planet Pharma
Planet Pharma is a global professional staffing company specializing in the pharmaceutical, biotechnology, device, and related industries. They offer experienced staff across various therapeutic and functional areas for all research and development phases, providing strategic solutions to clients worldwide.
Full Job Description
613284
Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes.
Required Skills:
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years’ experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Strong process development background
- Experience with Recombinant protein
- Experience with bispecific protein products
Responsibilities:
- Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
- Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.
- Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.
- Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
- Drive team engagement, ownership, and agility to deliver ambitious results.
- Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.
***Compensation within this range will be commensurate with level of experience***
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